Using Synthetic Biology to produce valuable compounds that cannot be made by Chemistry.
MISSION
Using Synthetic Biology to produce valuable compounds that cannot be made by Chemistry.
In the 20th century, Chemistry and related technologies solved many problems and enriched human society. However, people are now facing different types of problems such as the spread of new infectious viruses and antibiotic-resistant pathogens as well as climate change. We must explore new technologies that compensate for the limitations of Chemistry-based approaches.

Our laboratory uses a Synthetic Biology approach to solve the challenges above. Using artificially designed enzymes and microbes, we will produce a wide variety of compounds (Mw 100 - 1000) that cannot be synthesized by Chemistry. We believe that our research efforts contribute to addressing the above-mentioned serious problems.
MEMBERS
Principal Investigator
SATOSHI YUZAWA
Research fields
Synthetic Biology, Biochemistry, Chemical Biology
Publications
Contact
Email : syuzawa@ttck.keio.ac.jp
Research career
2020〜present
Project Assistant Professor (PI) at Keio University
2018〜2020
Project Assistant Professor at the University of Tokyo
2016〜2018
Biochemist Project Scientist at Lawrence Berkeley National Laboratory (United States)
2014〜2016
Assistant Project Scientist at University of California, Berkeley (United States)
2010〜2014
Postdoctoral Fellow at University of California, Berkeley (United States)
2009〜2010
Postdoctoral Fellow at Stanford University (United States)
2009
Doctor of Engineering at the University of Tokyo
Postdoctoral Fellow
MANAMI KATO
Research Assistant
MISAKI ASO
Research Assistant
HIROKO UEDA
Ph.D. Student
HIROMITSU YAMAMOTO
Ph.D. Student
TOMOKI TAKEDA
Master's Student
SHOTARO KATO
Master's Student
RENA SAITO
Undergraduate
RYUKI SATO
Undergraduate
KEIKA KUMAGAI
Undergraduate
KEIKA KUMAGAI
Undergraduate
SAWA YAMANE
High School Researcher
TAKUMA KONNO
High School Researcher
TAKUMA KONNO
RESEARCH
Our mission is “Using Synthetic Biology to produce valuable compounds that cannot be made by Chemisry”. Although Chemistry offers solutions with small molecules, it is extremely difficult to synthesize mid-sized molecules with multiple stereo centers. Synthetic Biology can solve this problem.

‍Our laboratory has focused on understanding mechanistic and structural features of gigantic enzymes represented by polyketide synthases and nonribosomal peptide synthetases, and exploting that knowledge for producing a variety of high-value chemicals in microbes from renewable resources.
NEWS
8/14/2023

Satoshi’s paper is published in Nat Commun!

7/26/2023

Rena Saito and Shotaro Kato's research has been selected for the Mori Yasuyoshiro Memorial Research Promotion Fund. Congratulations!

5/15/2023

Welcome Konoa Suda to our lab as a High School Researcher !

5/15/2023

Welcome Takuma Konno to our lab as a High School Researcher !

4/19/2023

Satoshi’s paper is published in JACS!

4/1/2023

Welcome Minjae Lee to our lab!

4/1/2023

Welcome Hiroko Ueda to our lab!

10/21/2022

Welcome Sawa Yamane to our lab!

10/21/2022

Welcome Keika Kumagai to our lab!

10/1/2022

Welcome Dr. Manami Kato to our lab!

10/1/2022

Welcome Shotaro Kato to our lab!

9/30/2022

Congratulations to Hiromitsu for receiving a JST research fellowship!

9/30/2022

Congratulations to Tomoki for receiving a JSPS research fellowship!

MORE NEWS
LABORATORY
The Institute for Advanced Biosciences at Keio University is known for one of the world's leading research facilities for metabolome analysis and provides a wide variety of research equipment that enables advanced R&D and technology demonstration.

In synthetic biology research, we design and build genetically engineered microbes and then test them by measuring their metabolomes. This Design-Build-Test cycle gives us big data to deeply interpret our enzyme/microbe designs (= Learn) by machine-learning etc.
MANUFACTURING BY SYNTHETIC BIOLOGY
CONTACT
246-2, Aza-mizukami, Kakuganji, Tsuruoka-shi, Yamagata
Institute of Advanced Life Sciences (IAB), Keio UniversityTSURUOKA Science Park
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